Controlling cravings is\u00a0an essential part of treatment, says\r\nDr Steve Brinksman.\r\n \r\n\r\nSean and I go back a long way. He first started treatment 15 years ago and has had quite a few treatment episodes over the period he has been with us. These tend to follow a pattern; he starts opioid substitution with methadone, titrates up to about 60mls at which point he stops using heroin.\r\n\r\nThen after a variable period of time \u2013 usually between four to 12 weeks \u2013 he starts to use again, occasionally at first and then more regularly, often missing pick-ups and appointments, before dropping out of treatment for a spell. Sometimes he comes back to us after a few months, sometimes more than a year goes by, and there have been interruptions while he has been in prison.\r\n\r\nHe has often done quite well in prison, away from his usual environment, and has been released on a moderate dose of methadone a number of times \u2013 but then the usual pattern kicks in. At the beginning of this year he told me he was fed up with this recurring sequence of events but not sure how we could change this.\r\n\r\nOn discussing his previous treatment episodes, he told me that when he started methadone he quite quickly stopped having withdrawal symptoms, and this was the point at which his dose titration stopped. However he would still crave heroin and despite his best intentions his resolve would eventually crack and he would use again; sometimes sporadically, but always increasing until the point of falling out of treatment.\r\n\r\nOn exploring this cycle with him, he felt there was constantly a trigger, like having extra money or bumping into the wrong people. Then it occurred to me that his craving might be the main factor, so we discussed increasing his dose beyond merely stopping withdrawal. I explained this didn\u2019t mean he would never come off treatment and that long-term abstinence could still be a goal; however to get to that point he first needed a sustained spell of not using heroin.\r\n\r\nHe agreed that we should try this and we titrated him over the next few weeks to 90mls of methadone. Nine months on he remains heroin free and is as well as I have ever seen him. I expect that at some point in the future he will want to try and reduce with a view to becoming abstinent. That will be at a time of his choosing, and meanwhile he is enjoying not constantly fighting against craving.\r\n\r\nSean has made me wonder if we often underdose with OST, in that we treat withdrawal symptoms yet leave our patients to deal with cravings. Is simply controlling withdrawal enough? It is gratifying to see this as an area picked up in the revised Drug Misuse and Dependence: UK Guidelines on Clinical Management (\u2018the Orange Book\u2019) and I now make a point of asking about craving as well as withdrawal symptoms, when assessing dose titrations.\r\n\r\nSteve Brinksman is a GP in Birmingham and clinical lead of SMMGP. He is also the RCGP regional lead in substance misuse for the West Midlands.